Brugada syndrome unmasked by malaria-induced fever.

ABSTRACT

Brugada syndrome is typically an autosomal dominant genetic disorder with variable expression, characterized by three specific electrocardiogram (ECG) patterns. While Type I Brugada ECG pattern is used as a classic marker for the disease, it is generally masked from ECG except in special cases such as malaria-induced fever. This vignette highlights a unique clinical scenario that can lead to the unmasking of Brugada type 1 pattern. <Learning objective: Brugada syndrome is associated with ventricular arrhythmias which if left untreated can result in syncope or premature death. Early intervention involving lifestyle modifications and recommendation of implantable defibrillator is based on diagnosis. Yet, Brugada syndrome is hard to detect from an electrocardiogram (ECG) alone. Still there are certain circumstances that unmask the Brugada syndrome ECG pattern. This case report provides one clinical scenario leading to the incidental unmasking of Brugada syndrome.>.