[Emphasizing the application of genetic diagnosis in branchio-oto-renal syndrome].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 32(16): 1226-1231, 2018 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-30282165
ABSTRACT
Summary Branchio-oto-renal syndrome (BOR) is an autosomal dominant genetic disorder characterized by branchial fistulas, hearing impairment, renal malformations and auricular anomalies. Pathogenic mutations have been discovered in several genes such as EYA1, SIX5, and SIX1. However, it has a high penetrance with variable expressivity. The clinical and genetical heterogeneity is widespread amongst and within families. In this review, we describe the clinical manifestations and pathogenic genes with copy number variations in detail, and emphasize the criteria clinically and genetically to provide the basis for clinical diagnosis of BOR and genetic counseling.
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MEDLINE
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Zh
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2018
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Article