Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?
Open Forum Infect Dis
; 5(10): ofy228, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30302354
ABSTRACT
BACKGROUND:
Chronic and granulomatous invasive fungal rhinosinusitis are important causes of blindness and craniocerebral complications. However, the classification of these 2 diseases remains controversial.METHODS:
We retrospectively analyzed patients with chronic and granulomatous invasive fungal rhinosinusitus in a Chinese tertiary hospital from 2009 to 2017, with a focus on classification and comparisons.RESULTS:
Among 55 patients enrolled in our study, 11 (11/55, 20%) had granulomatous invasive fungal rhinosinusitis (GIFRS) and 44 (44/55, 80%) had chronic invasive fungal rhinosinusitis (CIFRS). Aspergillus fumigatus and Dematiaceous hyphomycetes were identified in 2 patients with GIFRS. Compared with granulomatous type, CIFRS was more frequently encountered in immunocompromised patients (P = .022), and the time from onset to diagnosis was much shorter (P = .001). Proptosis and orbital apex syndrome showed no significant difference between granulomatous and CIFRS in our study. The treatment options and prognosis of both diseases also showed no significant difference.CONCLUSIONS:
Despite the consensus on histopathology, the classification of the chronic and granulomatous types may need further evaluation in clinical considerations.
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MEDLINE
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En
Ano de publicação:
2018
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Article