Impact of levodopa treatment in the voice pattern of Parkinson's disease patients: a systematic review and meta-analysis.
Codas
; 30(5): e20170200, 2018 Oct 04.
Article
em En
| MEDLINE
| ID: mdl-30304100
ABSTRACT
PURPOSE:
Investigate the association between levodopa therapy and vocal characteristics in Parkinson's disease patients. SEARCH STRATEGY Studies published at MEDLINE, LILACS, and SciELO, from 1960 to December 2016. A systematic review and meta-analysis was performed using the following keywords Parkinson's disease; levodopa; L-dopa; voice; speech disorders; dysphonia; dysarthria. After analyzing titles and abstracts, two independent reviewers selected all clinical trials that met the eligibility criteria and selected the articles and the data recorded in a previously standardized table. SELECTION CRITERIA Trials published in English between 1960 and December 2016 individuals with clinical diagnosis of Parkinson's disease; use of levodopa therapy in stable doses; acoustic analysis combined or not with auditory-perceptual analysis to evaluate the vocal parameters under investigation. DATAANALYSIS:
The following vocal parameters were analyzed fundamental frequency (F 0), jitter, and vocal intensity. Standardized mean differences (SMD) were calculated using the Comprehensive Meta-analysis V2 software.RESULTS:
Nine articles met the eligibility criteria and were selected, with a total of 119 individuals. From these, six articles with 83 individuals were included in the meta-analysis. During the levodopa therapy "on" state, modifications in F 0 (SMD=0.39; 95% CI - 0.21-0.57) and jitter (SMD=0.23; 95% CI - 0.02-0.45) were observed. Vocal intensity was not affected (SMD=0.09; 95% CI - 0.22-0.39) by levodopa ingestion. Data of the included studies were controversial in the auditory-perceptual analysis of voice.CONCLUSION:
Levodopa therapy modifies F0 and jitter. No changes in vocal intensity were observed in either the "on" or "off" states of levodopa therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Voz
/
Levodopa
/
Disartria
/
Disfonia
/
Antiparkinsonianos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article