Electrocardiographic left atrial abnormality and silent vascular brain injury: The Northern Manhattan Study.
PLoS One
; 13(10): e0203774, 2018.
Article
em En
| MEDLINE
| ID: mdl-30312297
ABSTRACT
HYPOTHESIS:
We hypothesized that P wave terminal Force in the V1 lead (PTFV1) would be associated with leukoaraiosis and subclinical infarcts, especially cortical infarcts, in a population-based, multi-ethnic cohort.METHODS:
PTFV1 was collected manually from baseline electrocardiograms of clinically stroke-free Northern Manhattan Study participants. Investigators read brain MRIs for superficial infarcts, deep infarcts, and white matter hyperintensity volume (WMHV). WMHV was adjusted for head size and log transformed, achieving a normal distribution. Logistic regression models investigated the association of PTFV1 with cortical and with all subclinical infarcts. Linear regression models examined logWMHV. Models were adjusted for demographics and risk factors.RESULTS:
Among 1174 participants with PTFV1 measurements, the mean age at MRI was 70 ± 9 years. Participants were 14.4% white, 17.6% black, and 65.8% Hispanic. Mean PTFV1 was 3587.35 ± 2315.62 µV-ms. Of the 170 subclinical infarcts, 40 were cortical. PTFV1 ≥ 5000 µV-ms was associated with WMHV in a fully adjusted model (mean difference in logWMHV 0.15, 95% confidence interval 0.01-0.28). PTFV1 exhibited a trend toward an association with cortical infarcts (unadjusted OR per SD change logPTFV1 1.30, 95% CI 0.94-1.81), but not with all subclinical infarcts.CONCLUSION:
Electrocardiographic evidence of left atrial abnormality was associated with leukoaraiosis.
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Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Acidente Vascular Cerebral
/
Traumatismo Cerebrovascular
/
Átrios do Coração
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article