Vacuum Sealing Drainage Therapy for Refractory Infectious Wound on 16 Renal Transplant Recipients.
Transplant Proc
; 50(8): 2479-2484, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30316382
ABSTRACT
BACKGROUND:
Refractory infectious wounds on renal transplantation (RT) recipients significantly prolong hospital stay, increase medical costs, and threaten allograft survival. Vacuum sealing drainage (VSD) therapy is a new technique for managing wounds based on the principle of application of controlled negative pressure. The aim of this study was to summarize the efficacy and safety of VSD therapy in the management of refractory infectious wounds following RT. MATERIALS ANDMETHODS:
This is a retrospective study of a cohort of 661 consecutive patients who received renal transplants over a period of 3 years in which the data were collected and analyzed retrospectively.RESULTS:
Out of the 661 patients, 16 (2.4%) developed refractory wound infection following RT. Nineteen organisms were identified by culture from all patients, including 10 patients infected with 1 or more bacteria, 2 patients with fungal infection, and 4 patients with both. Specifically, mucormycosis was demonstrated in 4 patients, pan-resistant Klebsiella pneumoniae in 2 patients, and Acinetobacter baumannii in 2 patients. All 16 patients were treated with VSD therapy for a median of 37 days (range, 6-111 days). The number of VSD sets used ranged from 4 to 28 sets (mean, 11.1 sets). A combination of antibiotics, debridement, and VSD therapy lead to 100% (16 of 16) wound healing. No VSD-relevant adverse events were observed.CONCLUSIONS:
VSD therapy is an effective and safe adjunct to conventional treatment modalities for the management of refractory wound infection following RT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecção dos Ferimentos
/
Transplante de Rim
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Tratamento de Ferimentos com Pressão Negativa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article