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A simplified pyrazinamidase test for pyrazinamide drug susceptibility in Mycobacterium tuberculosis.
Aono, Akio; Chikamatsu, Kinuyo; Yamada, Hiroyuki; Igarashi, Yuriko; Murase, Yoshiro; Takaki, Akiko; Mitarai, Satoshi.
Afiliação
  • Aono A; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan. Electronic address: aono@jata.or.jp.
  • Chikamatsu K; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan.
  • Yamada H; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan.
  • Igarashi Y; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan.
  • Murase Y; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan.
  • Takaki A; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan.
  • Mitarai S; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan anti-tuberculosis Association, Kiyose, Japan; Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Microbiol Methods ; 154: 52-54, 2018 11.
Article em En | MEDLINE | ID: mdl-30316980
ABSTRACT
We modified Wayne's pyrazinamidase test against Mycobacterium tuberculosis to indirectly measure pyrazinamidase activity via pyrazinoic acid in liquid medium. The modified pyrazinamidase test was easy to perform and its results were in complete agreement with those of the conventional Wayne's method, highlighting its potential application in phenotypic pyrazinamide susceptibility testing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinamida / Testes de Sensibilidade Microbiana / Testes Diagnósticos de Rotina / Amidoidrolases / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinamida / Testes de Sensibilidade Microbiana / Testes Diagnósticos de Rotina / Amidoidrolases / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2018 Tipo de documento: Article