Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.

Du, Kuo; Ramachandran, Anup; Weemhoff, James L; Woolbright, Benjamin L; Jaeschke, Andrew H; Chao, Xiaojuan; Ding, Wen-Xing; Jaeschke, Hartmut

Du, Kuo; Ramachandran, Anup; Weemhoff, James L; Woolbright, Benjamin L; Jaeschke, Andrew H; Chao, Xiaojuan; Ding, Wen-Xing; Jaeschke, Hartmut.

Afiliação

Du K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Weemhoff JL; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Woolbright BL; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Jaeschke AH; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Chao X; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Ding WX; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.
Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA. hjaeschke@kumc.edu.

Arch Toxicol ; 93(1): 163-178, 2019 01.

Article em En | MEDLINE | ID: mdl-30324313

Assuntos

Acetaminofen/intoxicação; Apoptose/efeitos dos fármacos; Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico; Compostos Organofosforados/farmacologia; Piperidinas/farmacologia; Acetilcisteína; Animais; Antioxidantes/farmacologia; Caspase 3/metabolismo; Hepatócitos/citologia; Hepatócitos/efeitos dos fármacos; Masculino; Camundongos Endogâmicos C57BL; Necrose; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo

Palavras-chave

Acetaminophen hepatotoxicity; Mito-Tempo; Mitochondria; Necrosis; Oxidative stress; Secondary apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Piperidinas / Apoptose / Doença Hepática Induzida por Substâncias e Drogas / Acetaminofen Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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