Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor/herbal therapy of breast cancer.
Nanomedicine (Lond)
; 13(20): 2637-2656, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30338705
ABSTRACT
AIM:
Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials &methodology:
The anionic CD44-targeting chondroitin sulfate and cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) were sequentially assembled onto the surface of the positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs were coupled to LF.RESULTS:
In vitro, fluorescence of QDs was quenched (OFF state) due to combined electron/energy transfer-mediated processes involving LF. After intracellular uptake of NCs, fluorescence was restored (ON state), thus enabled tracing their internalization. The NCs demonstrated enhanced cytotoxicity against breast cancer cells as well as superior in vivo antitumor efficacy.CONCLUSION:
We propose these multifunctional nanotheranostics for imaging and targeted therapy of breast cancer.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Nanocápsulas
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Nanomedicina Teranóstica
/
Lactoferrina
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article