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Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from ß2-microglobulin-deficient mice.
Masuda, Junko; Takayama, Eiji; Ichinohe, Tatsuo; Strober, Warren; Mizuno-Kamiya, Masako; Ikawa, Tomokatsu; Kitani, Atsushi; Kawaki, Harumi; Fuss, Ivan; Kawamoto, Hiroshi; Seno, Akimasa; Vaidyanath, Arun; Umemura, Naoki; Mizutani, Akifumi; Kasai, Tomonari; Honjo, Yasuko; Satoh, Ayano; Murakami, Hiroshi; Katsura, Yoshimoto; Kondoh, Nobuo; Seno, Masaharu.
Afiliação
  • Masuda J; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Takayama E; Laboratory of Host Defenses, Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ichinohe T; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
  • Strober W; Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
  • Mizuno-Kamiya M; Laboratory of Host Defenses, Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ikawa T; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
  • Kitani A; Laboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Kawaki H; Laboratory of Host Defenses, Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Fuss I; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
  • Kawamoto H; Laboratory of Host Defenses, Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Seno A; Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Vaidyanath A; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Umemura N; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Mizutani A; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
  • Kasai T; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Honjo Y; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Satoh A; Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
  • Murakami H; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Katsura Y; Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
  • Kondoh N; Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Seno M; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
Exp Ther Med ; 16(5): 4277-4282, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30344701
ABSTRACT
Administration of bone marrow-derived mesenchymal stem cells (MSCs) is a possible treatment for graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation and other inflammatory conditions. To address the mechanism of immunosuppression by MSCs, in particular those derived from adipose tissue (AMSCs), AMSCs were isolated from three different mouse strains, and the suppressive capacity of the AMSCs thus obtained to suppress interferon (IFN)-γ generation in mixed lymphocyte reaction cultures serving as an in vitro model of GVHD were assessed. It was revealed that the AMSCs had a potent capacity to suppress IFN-γ production regardless of their strain of origin and that such suppression was not associated with production of interleukin-10. In addition, the results demonstrated that ß2-microglobulin (ß2m)-deficient AMSCs from ß2m-/- mice were also potent suppressor cells, verifying the fact that the mechanism underlying the suppression by AMSCs is independent of major histocompatibility complex (MHC) class I expression or MHC compatibility. As AMSCs appear to have immunosuppressive properties, AMSCs may be a useful source of biological suppressor cells for the control of GVHD in humans.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article