[Randomized clinical trial of cis-platinum diamminedichloride (PDD) in the treatment of hepatocellular carcinoma (HCC)].
Zhonghua Zhong Liu Za Zhi
; 8(6): 467-9, 1986 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-3034538
ABSTRACT
From Oct. 1982 to Apr. 1985, 82 patients with HCC proven by pathology were treated in our hospital. 43 treated by hepatic arterial perfusion, were randomized into PDD group PDD 10 mg per day X 10, every 3 weeks; control group fluorouracil (5-Fu) 250 mg per day X 4, every week and thio-tepa (TSPA) 10 mg, twice a week. The other 39 treated by intravenous chemotherapy, were also randomized into PDD group PDD 20 mg per day X 5, every 3 weeks; control group 5-Fu 500 mg and TSPA 10 mg, twice a week. The objective response rates were 31.8% (7/22) in PDD group and 23.8% (5/21) in control group by hepatic arterial perfusion, and 20.0% (4/20) in the former and 0% (0/19) in the latter who were treated intravenously. The median survivals were 8 months for all the patients receiving hepatic arterial perfusion, and 6 and 5 months for the intravenous PDD and its control group, respectively. The side effects and kidney toxicity of PDD were tolerable to the patients. It is observed that PDD is better than 5-Fu and TSPA in the treatment of HCC.
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Base de dados:
MEDLINE
Assunto principal:
Cisplatino
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Idioma:
Zh
Ano de publicação:
1986
Tipo de documento:
Article