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Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities.
Zhang, Rui; Tang, Chunping; Liu, Hong-Chun; Ren, Yongmei; Xu, Cheng-Hui; Ke, Chang-Qiang; Yao, Sheng; Huang, Xun; Ye, Yang.
Afiliação
  • Zhang R; State Key Laboratory of Drug Research and Natural Products Chemistry Department , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Tang C; University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , China.
  • Liu HC; State Key Laboratory of Drug Research and Natural Products Chemistry Department , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Ren Y; SIMM-CUHK Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines , Shanghai 201203 , China.
  • Xu CH; Division of Antitumor Pharmacology , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Ke CQ; State Key Laboratory of Drug Research and Natural Products Chemistry Department , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Yao S; University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , China.
  • Huang X; School of Life Science and Technology , ShanghaiTech University , Shanghai 201210 , China.
  • Ye Y; Division of Antitumor Pharmacology , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
J Org Chem ; 83(22): 14175-14180, 2018 11 16.
Article em En | MEDLINE | ID: mdl-30345763
ABSTRACT
Ainsliatriolides A (1) and B (2), two guaianolide sesquiterpenoid trimers possessing an unprecedented skeleton, were isolated from Ainsliaea fragrans. Their structures were elucidated through extensive analysis of spectroscopic data and confirmed by single-crystal X-ray diffraction experiment. Ainsliatriolides A and B are first examples of compound trimerized from guaianolide sesquiterpenoids through two different C-C linkages (type A, 4-2'/15-14'; type B, 15'-15″). Ainsliatriolide A displayed potent cytotoxicity with an averaged IC50 value of 1.17 µM against four cancer cells.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Asteraceae / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Asteraceae / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article