Pharmacokinetic Study of Cefazolin in Short Daily Hemodialysis.
Ann Pharmacother
; 53(4): 348-356, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30345801
ABSTRACT
BACKGROUND:
A number of centers across the world offer short daily hemodialysis (SDHD) treatments. To date, cefazolin pharmacokinetics have not been described in patients undergoing SDHD.OBJECTIVE:
The purpose of this study was to investigate the effect of SDHD on the pharmacokinetics of cefazolin.METHODS:
This was a prospective, open-label, pharmacokinetic study of cefazolin during SDHD in 10 noninfected patients. Participants received a 1-g intravenous (IV) infusion of cefazolin after SDHD on study day 1 and a second dose after SDHD on study day 2. To determine the concentration of cefazolin, 6 blood samples were drawn at 0, 1, 2, 2.3, 4, and 24 hours after initiation of dialysis on day 2, and 2 dialysate samples were drawn at 1 and 2 hours after initiation of dialysis on day 2. Samples were analyzed using high-performance liquid chromatography, and pharmacokinetic parameters were determined.RESULTS:
Median interdialysis clearance was 0.16 L/h (interquartile range [IQR] 0.11-0.21 L/h), and median intradialysis clearance was 1.95 L/h (IQR 1.66-2.45 L/h). Median interdialysis half-life was 28.2 hours (IQR 23.5-59.3 hours) as compared with a median intradialysis half-life of 2.3 hours (IQR 1.7-2.7 hours). The median percentage removal of cefazolin during dialysis was 41% (IQR 35%-53%). Conclusion and Relevance Estimated cefazolin dialysis clearance is similar to previous estimates with conventional thrice-weekly regimens. Current dosing recommendations of 1 g IV post-SDHD achieve total serum drug concentrations greater than 40 mg/L in all patients, which is the total drug concentration required for bactericidal activity against Staphylococcus species.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cefazolina
/
Diálise Renal
/
Antibacterianos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article