SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.

Young, Lucy C; Hartig, Nicole; Boned Del Río, Isabel; Sari, Sibel; Ringham-Terry, Benjamin; Wainwright, Joshua R; Jones, Greg G; McCormick, Frank; Rodriguez-Viciana, Pablo

Young, Lucy C; Hartig, Nicole; Boned Del Río, Isabel; Sari, Sibel; Ringham-Terry, Benjamin; Wainwright, Joshua R; Jones, Greg G; McCormick, Frank; Rodriguez-Viciana, Pablo.

Afiliação

Young LC; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Hartig N; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Boned Del Río I; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Sari S; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Ringham-Terry B; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Wainwright JR; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Jones GG; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
McCormick F; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158 frank.mccormick@ucsf.edu p.rodriguez-viciana@ucl.ac.uk.
Rodriguez-Viciana P; University College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom; frank.mccormick@ucsf.edu p.rodriguez-viciana@ucl.ac.uk.

Proc Natl Acad Sci U S A ; 115(45): E10576-E10585, 2018 11 06.

Article em En | MEDLINE | ID: mdl-30348783

Assuntos

Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Síndrome de Noonan/metabolismo; Proteína Fosfatase 1/metabolismo; Quinases raf/metabolismo; Proteínas ras/metabolismo; Proteínas de Transporte; Linhagem Celular; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/genética; Sistema de Sinalização das MAP Quinases; Modelos Moleculares; Mutação; Síndrome de Noonan/genética; Fosforilação; Proteína Fosfatase 1/genética; Alinhamento de Sequência; Proteínas ras/genética

Palavras-chave

MRAS; Noonan syndrome; PP1; RAS; SHOC2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Quinases raf / Peptídeos e Proteínas de Sinalização Intracelular / Proteína Fosfatase 1 / Síndrome de Noonan Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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