Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes.

Frassanito, Maria Antonia; Desantis, Vanessa; Di Marzo, Lucia; Craparotta, Ilaria; Beltrame, Luca; Marchini, Sergio; Annese, Tiziana; Visino, Fabrizio; Arciuli, Marcella; Saltarella, Ilaria; Lamanuzzi, Aurelia; Solimando, Antonio G; Nico, Beatrice; De Angelis, Maria; Racanelli, Vito; Mariggiò, Maria A; Chiacchio, Rosistella; Pizzuti, Michele; Gallone, Anna; Fumarulo, Ruggiero; D'Incalci, Maurizio; Vacca, Angelo

Frassanito, Maria Antonia; Desantis, Vanessa; Di Marzo, Lucia; Craparotta, Ilaria; Beltrame, Luca; Marchini, Sergio; Annese, Tiziana; Visino, Fabrizio; Arciuli, Marcella; Saltarella, Ilaria; Lamanuzzi, Aurelia; Solimando, Antonio G; Nico, Beatrice; De Angelis, Maria; Racanelli, Vito; Mariggiò, Maria A; Chiacchio, Rosistella; Pizzuti, Michele; Gallone, Anna; Fumarulo, Ruggiero; D'Incalci, Maurizio; Vacca, Angelo.

Afiliação

Frassanito MA; Department of Biomedical Sciences and Human Oncology, Unit of General Pathology, University of Bari Aldo Moro Medical School, Bari, Italy.
Desantis V; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Di Marzo L; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Craparotta I; IRCCS - "Istituto di Ricerche Farmacologiche" Mario Negri, Milan, Italy.
Beltrame L; IRCCS - "Istituto di Ricerche Farmacologiche" Mario Negri, Milan, Italy.
Marchini S; IRCCS - "Istituto di Ricerche Farmacologiche" Mario Negri, Milan, Italy.
Annese T; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro Medical School, Bari, Italy.
Visino F; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Arciuli M; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro Medical School, Bari, Italy.
Saltarella I; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Lamanuzzi A; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Solimando AG; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Nico B; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro Medical School, Bari, Italy.
De Angelis M; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Racanelli V; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Mariggiò MA; Department of Biomedical Sciences and Human Oncology, Unit of General Pathology, University of Bari Aldo Moro Medical School, Bari, Italy.
Chiacchio R; Unit of Pathologic Anatomy and Cytodiagnosis, San Carlo Hospital, Potenza, Italy.
Pizzuti M; Unit of Hematology, San Carlo Hospital, Potenza, Italy.
Gallone A; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro Medical School, Bari, Italy.
Fumarulo R; Department of Biomedical Sciences and Human Oncology, Unit of General Pathology, University of Bari Aldo Moro Medical School, Bari, Italy.
D'Incalci M; IRCCS - "Istituto di Ricerche Farmacologiche" Mario Negri, Milan, Italy.
Vacca A; Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.

J Pathol ; 247(2): 241-253, 2019 02.

Article em En | MEDLINE | ID: mdl-30357841

Assuntos

Células da Medula Óssea/metabolismo; Exossomos/metabolismo; Fibroblastos/metabolismo; MicroRNAs/metabolismo; Gamopatia Monoclonal de Significância Indeterminada/metabolismo; Mieloma Múltiplo/metabolismo; Actinas/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Apoptose; Células da Medula Óssea/patologia; Células Cultivadas; Progressão da Doença; Endopeptidases; Exossomos/genética; Exossomos/patologia; Proteína 7 com Repetições F-Box-WD/genética; Proteína 7 com Repetições F-Box-WD/metabolismo; Feminino; Fibroblastos/patologia; Gelatinases/metabolismo; Regulação Neoplásica da Expressão Gênica; Humanos; Masculino; Proteínas de Membrana/metabolismo; MicroRNAs/genética; Pessoa de Meia-Idade; Gamopatia Monoclonal de Significância Indeterminada/genética; Gamopatia Monoclonal de Significância Indeterminada/patologia; Mieloma Múltiplo/genética; Mieloma Múltiplo/patologia; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Serina Endopeptidases/metabolismo; Transdução de Sinais; Microambiente Tumoral; Regulação para Cima

Palavras-chave

MGUS; bone marrow fibroblasts; exosomes; miRNAs; multiple myeloma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gamopatia Monoclonal de Significância Indeterminada / Células da Medula Óssea / MicroRNAs / Exossomos / Fibroblastos / Mieloma Múltiplo Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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