Regeneration of Osteochondral Defects Using Developmentally Inspired Cartilaginous Templates.
Tissue Eng Part A
; 25(3-4): 159-171, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30358516
ABSTRACT
IMPACT STATEMENT Successfully treating osteochondral defects involves regenerating both the damaged articular cartilage and the underlying subchondral bone, in addition to the complex interface that separates these tissues. In this study, we demonstrate that a cartilage template, engineered using bone marrow-derived mesenchymal stem cells, can enhance the regeneration of such defects and promote the development of a more mechanically functional repair tissue. We also use a computational mechanobiological model to understand how joint-specific environmental factors, specifically oxygen levels and tissue strains, regulate the conversion of the engineered template into cartilage and bone in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Osso e Ossos
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Cartilagem Articular
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Condrogênese
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Transplante de Células-Tronco Mesenquimais
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Células-Tronco Mesenquimais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article