Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations.
Science
; 362(6413): 457-460, 2018 10 26.
Article
em En
| MEDLINE
| ID: mdl-30361373
ABSTRACT
The color patterns of African cichlid fishes provide notable examples of phenotypic convergence. Across the more than 1200 East African rift lake species, melanic horizontal stripes have evolved numerous times. We discovered that regulatory changes of the gene agouti-related peptide 2 (agrp2) act as molecular switches controlling this evolutionarily labile phenotype. Reduced agrp2 expression is convergently associated with the presence of stripe patterns across species flocks. However, cis-regulatory mutations are not predictive of stripes across radiations, suggesting independent regulatory mechanisms. Genetic mapping confirms the link between the agrp2 locus and stripe patterns. The crucial role of agrp2 is further supported by a CRISPR-Cas9 knockout that reconstitutes stripes in a nonstriped cichlid. Thus, we unveil how a single gene affects the convergent evolution of a complex color pattern.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pigmentação da Pele
/
Ciclídeos
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Evolução Biológica
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Proteína Relacionada com Agouti
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article