Synthesis of Multifunctional Homopolymers through Using Thiazolidine Chemistry and Post-Polymerization Modification.
Macromol Rapid Commun
; 40(1): e1800590, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30368966
ABSTRACT
Multifunctional homopolymers, defined here as polymers that contain multiple reactive functional groups per repeat unit, are versatile scaffolds for preparing complex macromolecules via post-polymerization modification. However, there are limited methods for preparing multifunctional homopolymers that contain more than one nucleophilic site per repeat unit. Herein, a strategy to synthesize a multifunctional homopolymer using thiazolidine chemistry is demonstrated. Controlled radical polymerization of a thiazolidine-containing acrylamido monomer allows for the synthesis of a polymer with pendent latent nucleophiles. Ring-opening of the thiazolidine affords a homopolymer with two side-chain reactive sites, an amine and a thiol. One-pot functionalization via disulfide formation and acyl substitution is performed to introduce two distinct groups in each repeat unit.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Tiazolidinas
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article