Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nat Commun
; 9(1): 4516, 2018 10 30.
Article
em En
| MEDLINE
| ID: mdl-30375396
ABSTRACT
Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8+ T cells (TVM) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the TVM compartment. Here, we show that helminths expand CD44hiCD62LhiCXCR3hiCD49dlo TVM cells through direct IL-4 signaling in CD8+ T cells. Importantly, helminth-mediated conditioning of TVM cells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8+ T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8+ T cells, leading to a subsequently raised antigen-specific CD8+ T cell activation that enhances control of viral infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Infecções Tumorais por Vírus
/
Esquistossomose mansoni
/
Interleucina-4
/
Infecções por Herpesviridae
/
Linfócitos T CD8-Positivos
/
Memória Imunológica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article