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The XL probe: A luxury or a necessity? Risk stratification in an obese community cohort using transient elastography.
Harris, Rebecca; Card, Timothy R; Delahooke, Toby; Aithal, Guruprasad P; Guha, I Neil.
Afiliação
  • Harris R; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, UK.
  • Card TR; Division of Epidemiology and Public Health, University of Nottingham, UK.
  • Delahooke T; Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK.
  • Aithal GP; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, UK.
  • Guha IN; Nottingham Digestive Diseases Centre, University of Nottingham, UK.
United European Gastroenterol J ; 6(9): 1372-1379, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30386610
BACKGROUND: Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. OBJECTIVE: The purpose of this study was to analyse the performance of two probes (M/XL) on a portable transient elastography device within an obese community population. METHOD: The method involved a prospective study with recruitment from a primary care practice. Patients identified with a risk factor for chronic liver disease were invited to a community-based risk stratification pathway for transient elastography readings with both probes. A threshold of ≥8.0 kPa defined elevated liver stiffness. RESULTS: A total of 477 patients attended the pathway. Of the patients, 21% had no valid measurements with the M probe. There was a significant difference between the probes in the proportion achieving ≥10 valid readings (M versus XL probe: 66.2% versus 90.2%; p ≤ 0.001) and in their reliability (M versus XL probe: 77.4% versus 98.5%; p = 0.028). Unreliable readings with the M probe increased as the body mass index increased. The XL probe re-stratified 5.2% of patients to have a normal reading. CONCLUSION: The XL probe on a portable device significantly improves the applicability of transient elastography within a community-based risk stratification pathway.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article