Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease.

Yusuf, Issa Olakunle; Chen, Hsiu-Mei; Cheng, Pei-Hsun; Chang, Chih-Yi; Tsai, Shaw-Jenq; Chuang, Jih-Ing; Wu, Chia-Ching; Huang, Bu-Miin; Sun, H Sunny; Yang, Shang-Hsun

Yusuf, Issa Olakunle; Chen, Hsiu-Mei; Cheng, Pei-Hsun; Chang, Chih-Yi; Tsai, Shaw-Jenq; Chuang, Jih-Ing; Wu, Chia-Ching; Huang, Bu-Miin; Sun, H Sunny; Yang, Shang-Hsun.

Afiliação

Yusuf IO; Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Cheng Kung University and Academia Sinica, Taipei 11529, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Department of Physiology, College of Medicine, National Cheng Kung
Chen HM; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Cheng PH; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chang CY; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Tsai SJ; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan.
Chuang JI; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan.
Wu CC; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan; Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan 70101, Taiwan.
Huang BM; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan; Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan 70101, Taiwan.
Sun HS; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Molecular Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yang SH; Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Cheng Kung University and Academia Sinica, Taipei 11529, Taiwan; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, National Cheng

Free Radic Biol Med ; 130: 256-266, 2019 01.

Article em En | MEDLINE | ID: mdl-30391672

Assuntos

Antioxidantes/farmacologia; Encéfalo/metabolismo; Fator 9 de Crescimento de Fibroblastos/genética; Doença de Huntington/tratamento farmacológico; Fator 2 Relacionado a NF-E2/genética; Animais; Encéfalo/patologia; Linhagem Celular; Regulação da Expressão Gênica/efeitos dos fármacos; Glutamato-Cisteína Ligase/genética; Glutationa Redutase/genética; Humanos; Proteína Huntingtina/genética; Doença de Huntington/genética; Doença de Huntington/patologia; Sistema de Sinalização das MAP Quinases/genética; Camundongos; Fármacos Neuroprotetores/farmacologia; Estresse Oxidativo/efeitos dos fármacos; Superóxido Dismutase/genética; Córtex Visual/metabolismo; Córtex Visual/patologia

Palavras-chave

Anti-oxidative functions; ERK signalling; Fibroblast Growth Factor 9; Huntington's disease; Nrf2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Doença de Huntington / Fator 9 de Crescimento de Fibroblastos / Fator 2 Relacionado a NF-E2 / Antioxidantes Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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