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Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients.
Wang, Yu-Qin; Dai, Xiao-Dan; Ran, Yun; Cao, Ying; Lan, Chun-Lin; Guan, Ji-Tian; Liu, Chang; Yang, Feng-Mei; Gan, Yi-Jing; Liu, Bai-Jing; Fang, Ai-Wu; Lin, Dan; Gong, Xian-Hui; Cui, Ren-Zhe; Jin, Zi-Bing; Qu, Jia; Lu, Fan; Chi, Zai-Long.
Afiliação
  • Wang YQ; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Dai XD; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Ran Y; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Cao Y; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Lan CL; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Guan JT; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Liu C; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Yang FM; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Gan YJ; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Liu BJ; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Fang AW; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Lin D; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Gong XH; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Cui RZ; Department of Ophthalmology, Affiliated Hospital of Yanbian University, Yanji, Jilin, P. R. China.
  • Jin ZB; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Qu J; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Lu F; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
  • Chi ZL; State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Ocul Immunol Inflamm ; 28(1): 133-141, 2020.
Article em En | MEDLINE | ID: mdl-30395736
ABSTRACT

Purpose:

To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity.

Methods:

A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls.

Results:

S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values.

Conclusion:

Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Uveíte / Biomarcadores / Calgranulina A / Calgranulina B / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Uveíte / Biomarcadores / Calgranulina A / Calgranulina B / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article