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Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.
Chamberlain, Jeffrey M; Sortino, Katherine; Sethna, Phiroze; Bae, Andrew; Lanier, Randall; Bambara, Robert A; Dewhurst, Stephen.
Afiliação
  • Chamberlain JM; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
  • Sortino K; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
  • Sethna P; Chimerix, Durham, North Carolina, USA.
  • Bae A; Chimerix, Durham, North Carolina, USA.
  • Lanier R; Chimerix, Durham, North Carolina, USA.
  • Bambara RA; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
  • Dewhurst S; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA Stephen_Dewhurst@urmc.rochester.edu.
Antimicrob Agents Chemother ; 63(1)2019 01.
Article em En | MEDLINE | ID: mdl-30397065
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas Virais / DNA Viral / Adenovírus Humanos / Citosina / DNA Polimerase Dirigida por DNA / Organofosfonatos / Cidofovir Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas Virais / DNA Viral / Adenovírus Humanos / Citosina / DNA Polimerase Dirigida por DNA / Organofosfonatos / Cidofovir Idioma: En Ano de publicação: 2019 Tipo de documento: Article