Evolution of commercially available compounds for HTS.
Drug Discov Today
; 24(2): 390-402, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30399443
ABSTRACT
Over recent years, an industry of compound suppliers has grown to provide drug discovery with screening compounds it is estimated that there are over 16 million compounds available from these sources. Here, we review the chemical space covered by suppliers' compound libraries (SCL) in terms of compound physicochemical properties, novelty, diversity, and quality. We examine the feasibility of compiling high-quality vendor-based libraries avoiding complicated, expensive compound management activity, and compare the resulting libraries to the ChEMBL data set. We also consider how vendors have responded to the evolving requirements for drug discovery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Ensaios de Triagem em Larga Escala
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article