Epidemiology of Moyamoya Disease in China: Single-Center, Population-Based Study.
World Neurosurg
; 122: e917-e923, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30404059
ABSTRACT
BACKGROUND:
To our knowledge, no previous study has described the nationwide epidemiologic features of moyamoya disease (MMD) in China. We describe the epidemiologic features including the relative prevalence, age distribution, gender distribution, and initial clinical manifestations of patients with MMD treated at a single institution in China.METHODS:
Our cohort included 4128 patients with MMD. Their demographic and clinical characteristics were obtained by retrospective chart review.RESULTS:
The median age for the onset of symptoms was 30.36 years. The age distribution of patients with MMD was bimodal, with the highest peak detection rate at 35-45 years of age and a smaller peak at 5-9 years of age. The ratio of female-to-male patients was 11. The disease occurred mainly in the Han people and was rarely seen in minority nationalities. In our cohort, transient ischemic attack was the most common initial clinical manifestation (48.13%). The other initial manifestations included infarction (22.62%), hemorrhage (16.45%), and headache 230/4128 (5.57%). In north and northeast China, the ischemic type was more predominate while the hemorrhagic type was relatively rare. However, the percentage of hemorrhagic type in East China was higher than anywhere else in China.CONCLUSIONS:
This study confirmed some unique epidemiologic features as the studies previously reported in China, but it also revealed some new sight and tendency about moyamoya in China. As a lack of national epidemiologic studies, this study indicated the outline of moyamoya in China.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Vigilância da População
/
Doença de Moyamoya
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article