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Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population.
Zhou, Hai; Huang, Huaxing; You, Zebin; Shadhu, Kamleshsingh; Ramlagun, Dadhija; Qiang, Cao; Li, Pu; Qi, Lezhong; Shen, Yuyong; Zhou, Ming; Chen, Yuming; Fei, Shangchun; Wang, Xiaoxiang.
Afiliação
  • Zhou H; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Huang H; First Clinical College, Nanjing Medical University, Nanjing.
  • You Z; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Shadhu K; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Ramlagun D; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Qiang C; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Li P; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Qi L; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Shen Y; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Zhou M; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Chen Y; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Fei S; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
  • Wang X; Department of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Medicine (Baltimore) ; 97(45): e13037, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30407299
The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population.This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay.We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively).Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Etnicidade / Receptores de Detecção de Cálcio / Nefrolitíase Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Etnicidade / Receptores de Detecção de Cálcio / Nefrolitíase Idioma: En Ano de publicação: 2018 Tipo de documento: Article