From VA Larynx to the future of chemoselection: Defining the role of induction chemotherapy in larynx cancer.
Oral Oncol
; 86: 200-205, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30409302
ABSTRACT
Organ preservation protocols utilizing induction chemotherapy as a selection agent have played a critical role in the treatment of advanced laryngeal squamous cell carcinoma (LSCC). The selection of patients who will have a good response to chemoradiation allows for organ preservation in a significant group of patients and minimizes the rate of surgical salvage. While there remains debate regarding its utility when compared to surgery or other organ preservation regimens, the data does suggest an important role for induction chemotherapy in LSCC. In addition, there are continued opportunities to identify pretreatment biomarkers for induction chemotherapy, whether genetic, epigenetic or cellular, that could predict response to treatment and select patients to therapy (whether organ preservation or surgery). As our understanding of the biology of larynx cancer advances, induction paradigms have utility for the development and adoption of novel agents and therapeutics. The background of induction chemotherapy as a selection agent and future directions of this approach are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Neoplasias Laríngeas
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Seleção de Pacientes
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Quimioterapia de Indução
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Carcinoma de Células Escamosas de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article