Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation.

Wu, Chao; Chen, Weiyang; Fang, Meng; Boye, Alex; Tao, Xiangming; Xu, Yuanyuan; Hou, Shu; Yang, Yan

Wu, Chao; Chen, Weiyang; Fang, Meng; Boye, Alex; Tao, Xiangming; Xu, Yuanyuan; Hou, Shu; Yang, Yan.

Afiliação

Wu C; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Chen W; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Fang M; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Boye A; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Tao X; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Xu Y; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China.
Hou S; Department of Pediatrics, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
Yang Y; Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China. Electronic address: yangyan@ahmu.edu.cn.

J Ethnopharmacol ; 231: 98-112, 2019 Mar 01.

Article em En | MEDLINE | ID: mdl-30412748

Assuntos

Antineoplásicos Fitogênicos; Astrágalo; Carcinoma Hepatocelular; Neoplasias Hepáticas; MicroRNAs/metabolismo; Extratos Vegetais; Salvia miltiorrhiza; Proteína Smad3/metabolismo; Animais; Antineoplásicos Fitogênicos/farmacologia; Antineoplásicos Fitogênicos/uso terapêutico; Carcinoma Hepatocelular/induzido quimicamente; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/metabolismo; Dietilnitrosamina; Células Hep G2; Humanos; Neoplasias Hepáticas/induzido quimicamente; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/metabolismo; Masculino; Camundongos Nus; Fosforilação/efeitos dos fármacos; Extratos Vegetais/farmacologia; Extratos Vegetais/uso terapêutico; Ratos Sprague-Dawley; Proteína Smad3/genética

Palavras-chave

CASE; HCC; MAPK; Smad3 phosphorylation; miR-145; miR-21

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Carcinoma Hepatocelular / Astrágalo / Salvia miltiorrhiza / MicroRNAs / Proteína Smad3 / Neoplasias Hepáticas / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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