Inflammatory biomarkers in psychosis and clinical high risk populations.
Schizophr Res
; 206: 440-443, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30414721
ABSTRACT
BACKGROUND:
Immunological, nutritional, and microbial factors have been implicated in the pathophysiology of schizophrenia, but the interrelationship among measures is understudied. In particular, an increase in the levels of the pro-inflammatory cytokine interleukin-6 (IL-6) is associated with all phases of the illness, and may be associated with other inflammatory markers. Vitamin D is a modulator of the immune system, and LPS antibodies are an indirect measure of gut barrier function. In this study we investigated potential contributing inflammatory mechanisms for IL-6 elevation.METHODS:
We compared the levels of vitamin D, C-reactive protein (CRP), antibodies to lipopolysaccharide (LPS), and IL-6 in children, adolescents and young adults with psychosis (nâ¯=â¯47), individuals at clinical high risk for psychosis (nâ¯=â¯17) and unaffected comparison controls (nâ¯=â¯33). Participants were diagnosed by a psychiatrist, using a structured interview, the MINI-Neuropsychiatric Interview. 25(OH)D was measured in serum using chemiluminescent micro particle immunoassay, and anti-LPS antibodies, CRP and IL-6 levels were measured by ELISA.RESULTS:
IL-6 and C-reactive protein levels were significantly elevated in the psychosis group relative to the unaffected control subjects. In the psychosis group, levels of IL-6 correlated positively with IgA anti-LPS antibodies and negatively correlated with vitamin D.CONCLUSIONS:
Our findings show a significant correlation between IL-6, anti-LPS antibodies and vitamin D deficiency in psychosis, suggesting the existence of multiple potential pathways related to IL-6 elevation in psychosis, and therefore multiple potential strategies for risk mitigation. Collectively these findings support hypotheses regarding interrelated inflammatory contributions to the pathophysiology of psychosis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
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Interleucina-6
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Inflamação
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article