Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo.

Zeng, Baishuang; Chai, Jinwei; Deng, Zhenhui; Ye, Tiaofei; Chen, Wenbin; Li, Dan; Chen, Xin; Chen, Ming; Xu, Xueqing

Zeng, Baishuang; Chai, Jinwei; Deng, Zhenhui; Ye, Tiaofei; Chen, Wenbin; Li, Dan; Chen, Xin; Chen, Ming; Xu, Xueqing.

Afiliação

Zeng B; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Chai J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Deng Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Ye T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Chen W; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Li D; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Chen X; Department of Respiratory Medicine , Zhujiang Hospital, Southern Medical University , Guangzhou 510282 , China.
Chen M; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin 541004 , China.
Xu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.

J Med Chem ; 61(23): 10709-10723, 2018 12 13.

Article em En | MEDLINE | ID: mdl-30427189

Assuntos

Anti-Infecciosos/metabolismo; Anti-Infecciosos/farmacologia; Anti-Inflamatórios/metabolismo; Anti-Inflamatórios/farmacologia; Lipopolissacarídeos/metabolismo; Peptídeos/metabolismo; Peptídeos/farmacologia; Sequência de Aminoácidos; Animais; Anti-Infecciosos/química; Anti-Inflamatórios/química; Bactérias/citologia; Bactérias/efeitos dos fármacos; Linhagem Celular; Membrana Celular/efeitos dos fármacos; Citocinas/biossíntese; Descoberta de Drogas; Feminino; Humanos; Cinética; Lipopolissacarídeos/farmacologia; Masculino; Camundongos; Testes de Sensibilidade Microbiana; Modelos Moleculares; Óxido Nítrico/biossíntese; Peptídeos/química; Estrutura Secundária de Proteína; Ranidae

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Lipopolissacarídeos / Anti-Infecciosos / Anti-Inflamatórios Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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