A Wireless Optoelectronic Neuroscience Platform for Chronic Fluorescence Sensing in Freely Behaving Rodents.
Annu Int Conf IEEE Eng Med Biol Soc
; 2018: 1608-1611, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30440700
ABSTRACT
We present a new head mountable wireless fiber biophotometry microsystem conceived to detect fluorescent signal fluctuations correlated with neuronal activity. The proposed system incorporates all aspects of a conventional tethered fiber-based biophotometry system encompassed into a wireless microsystem. The interface includes an LED as excitation light source, a custom designed CMOS biosensor, a multimode fiber, a microcontroller (MCU), and a wireless data transceiver enclosed within a 3D-printed, small and light weight, plastic housing. Precisely, the system incorporates a new optoelectronic biosensor merging two individual building blocks, namely a low-noise sensing front-end and $\mathrm {a}2 ^{nd}$ order continuous-time $\Sigma \Delta $ modulator (CTSDM), into a single module for enabling high-sensitivity and high energy-efficiency photo-sensing. The proposed CMOS biosensor is implemented in $\mathrm {a}0 .18- \mu m$ CMOS technology, consuming $41 \mu W$ from $\mathrm {a}1 .8- V$ supply voltage, while achieving a peak dynamic range of $86 dB$ over a $50- Hz$ input bandwidth at a 20-kS/s sampling rate. This new interface opens new avenues for conducting in-vivo experiments with live animals.
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1
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
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Tecnologia sem Fio
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Sistema Nervoso
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article