Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report.
Auris Nasus Larynx
; 46(5): 813-817, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-30442438
ABSTRACT
CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Computed tomography and magnetic resonance imaging performed 10 weeks after the primary treatment revealed a residual tumor and brain and lung metastases. Thereafter, chemotherapy comprising cisplatin, 5-FU, and cetuximab was performed. Unfortunately, the tumor volume increased 5 months after chemotherapy, after which she received immunotherapy with biweekly nivolumab. After six cycles of nivolumab administration, the brain and lung metastases shrank markedly. Nivolumab had an intracranial effect in the patient with brain metastases of parotid carcinoma. This case report highlights the efficacy of nivolumab in the management of head and neck cancer with brain metastasis.
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MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Neoplasias Parotídeas
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Antineoplásicos Imunológicos
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Carcinoma de Células Escamosas de Cabeça e Pescoço
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Nivolumabe
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Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article