Sensing Mitochondrial Acetyl-CoA to Tune Respiration.
Trends Endocrinol Metab
; 30(1): 1-3, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30442533
ABSTRACT
Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilcoenzima A
/
Respiração
/
Proteína de Transporte de Acila
/
Ácidos Graxos
/
Eucariotos
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article