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Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.
Steklov, M; Pandolfi, S; Baietti, M F; Batiuk, A; Carai, P; Najm, P; Zhang, M; Jang, H; Renzi, F; Cai, Y; Abbasi Asbagh, L; Pastor, T; De Troyer, M; Simicek, M; Radaelli, E; Brems, H; Legius, E; Tavernier, J; Gevaert, K; Impens, F; Messiaen, L; Nussinov, R; Heymans, S; Eyckerman, S; Sablina, A A.
Afiliação
  • Steklov M; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Pandolfi S; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Baietti MF; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Batiuk A; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Carai P; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Najm P; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Zhang M; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Jang H; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Renzi F; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Cai Y; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Abbasi Asbagh L; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Pastor T; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
  • De Troyer M; Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
  • Simicek M; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Radaelli E; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Brems H; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Legius E; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Tavernier J; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Gevaert K; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Impens F; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Messiaen L; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Nussinov R; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Heymans S; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Eyckerman S; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  • Sablina AA; Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Science ; 362(6419): 1177-1182, 2018 12 07.
Article em En | MEDLINE | ID: mdl-30442762
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas ras / Ubiquitinação / Síndrome de Noonan Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas ras / Ubiquitinação / Síndrome de Noonan Idioma: En Ano de publicação: 2018 Tipo de documento: Article