Methylation and Acetylation Enhanced the Antidiabetic Activity of Some Selected Flavonoids: In Vitro, Molecular Modelling and Structure Activity Relationship-Based Study.

Ahmed, Qamar Uddin; Sarian, Murni Nazira; Mat So'ad, Siti Zaiton; Latip, Jalifah; Arief Ichwan, Solachuddin Jauhari; Hussein, Nurlaili Najmie; Taher, Muhammad; Alhassan, Alhassan Muhammad; Hamidon, Hanisuhana; Fakurazi, Sharida

Ahmed, Qamar Uddin; Sarian, Murni Nazira; Mat So'ad, Siti Zaiton; Latip, Jalifah; Arief Ichwan, Solachuddin Jauhari; Hussein, Nurlaili Najmie; Taher, Muhammad; Alhassan, Alhassan Muhammad; Hamidon, Hanisuhana; Fakurazi, Sharida.

Afiliação

Ahmed QU; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. quahmed@iium.edu.my.
Sarian MN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. murninazira88@gmail.com.
Mat So'ad SZ; Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. murninazira88@gmail.com.
Latip J; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. dszaiton@iium.edu.my.
Arief Ichwan SJ; School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia. jalifah@ukm.edu.my.
Hussein NN; Faculty of Dentistry, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. solachuddin@iium.edu.my.
Taher M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. lailinajmie@yahoo.com.
Alhassan AM; Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. mtaher@iium.edu.my.
Hamidon H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. alhasanma@yahoo.com.
Fakurazi S; Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang DM, Malaysia. hanisuhana.hamidon@gmail.com.

Biomolecules ; 8(4)2018 11 15.

Article em En | MEDLINE | ID: mdl-30445784

Assuntos

Flavonoides/química; Flavonoides/farmacologia; Hipoglicemiantes/química; Hipoglicemiantes/farmacologia; Modelos Moleculares; Células 3T3-L1; Acetilação; Adipócitos/efeitos dos fármacos; Adipócitos/metabolismo; Adipogenia/efeitos dos fármacos; Adipocinas/metabolismo; Animais; Proteínas Estimuladoras de Ligação a CCAAT/metabolismo; Domínio Catalítico; Sobrevivência Celular/efeitos dos fármacos; Diabetes Mellitus Tipo 2/patologia; Glucose/metabolismo; Transportador de Glucose Tipo 1/química; Transportador de Glucose Tipo 1/metabolismo; Transportador de Glucose Tipo 4/metabolismo; Secreção de Insulina/efeitos dos fármacos; Gotículas Lipídicas/metabolismo; Metilação; Camundongos; Simulação de Acoplamento Molecular; Ratos; Relação Estrutura-Atividade

Palavras-chave

3T3-L1 pre-adipocytes; RIN-5F pancreatic cells; SAR; adipokines; flavonoids; molecular docking; type 2 diabetes mellitus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Modelos Moleculares / Hipoglicemiantes Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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