A placebo controlled treatment trial of sertraline and interpersonal psychotherapy for postpartum depression.
J Affect Disord
; 245: 524-532, 2019 02 15.
Article
em En
| MEDLINE
| ID: mdl-30447565
ABSTRACT
BACKGROUND:
The purpose of the present study was to test the efficacy of sertraline and Interpersonal Psychotherapy (IPT) relative to pill placebo in a two site randomized controlled trial over a period of 12 weeks. It was hypothesized that sertraline and IPT would be more efficacious than pill placebo with respect to depression and social adjustment.METHODS:
162 breastfeeding and non-breastfeeding women experiencing a major depressive episode in the first year postpartum from two sites in Iowa and Rhode Island were randomly assigned to IPT, sertraline-clinical management (CM), or pill placebo-CM. CM included infant-focused psychoeducation. Interview-based and self-report measures of depression and social adjustment were obtained at baseline, 4-weeks, 8-weeks, and 12-weeks of treatment. Linear mixed effects regression (LMER) was used for the longitudinal data analysis.RESULTS:
There was no significant effect for treatment condition associated with the primary outcome measure, the HamD-17, but there was a significant effect for sertraline-CM relative to the IPT and placebo conditions over the duration of the trial based on the General Depression scale of the Inventory of Depression and Anxiety Symptoms. There was a main effect for time in that study subjects across all three conditions showed significant improvement for the duration of the trial.LIMITATIONS:
Limitations of the present study included significant non-engagement with assigned condition and differential effects of IPT across the two study sites.CONCLUSIONS:
There was improvement for all postpartum women in all conditions. The results do suggest that active interventions with or without medication delivered over a period of twelve weeks can lead to significant improvement in depression and social adjustment among postpartum women. ClinicalTrials.gov identifier NCT00602355.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressão Pós-Parto
/
Sertralina
/
Psicoterapia Centrada na Pessoa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article