Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction.
Ultrasound Med Biol
; 45(2): 568-578, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30467033
ABSTRACT
We evaluated the relationships between regional myocardial strain measured by speckle tracking echocardiography and viability, fibrosis, hypertrophy and oxygen consumption in the infarcted or remote myocardium in a pig model of chronic myocardial infarction (MI). Thirteen farm pigs with surgical occlusion of the left anterior descending coronary artery and five sham-operated pigs were studied 3 mo post-MI. Computed tomography revealed significant left ventricle remodeling. Reduced radial or circumferential strain identified areas of transmural infarction (area under the curve 0.82 and 0.79, respectively). In the remote non-infarcted area, radial strain correlated inversely with the amount of fibrosis (râ¯=â¯-0.66, pâ¯=â¯0.04) and myocyte hypertrophy (râ¯=â¯-0.68, pâ¯=â¯0.03). Radial strain rate inversely correlated with myocardial resting oxygen consumption assessed with 11C-labeled acetate positron emission tomography (râ¯=â¯-0.71, pâ¯=â¯0.006). In conclusion, myocardial strain and strain rate reflect fibrosis, hypertrophy and oxygen consumption of the remote areas after MI.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ecocardiografia
/
Coração
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article