MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming.
Stem Cell Reports
; 11(6): 1479-1492, 2018 12 11.
Article
em En
| MEDLINE
| ID: mdl-30472011
ABSTRACT
Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood. By using cellular, biochemical, protein array, metabolomic, and respirometry analyses, we found that c-MYC establishes a robust bivalent energetics program early in cell reprogramming. Cells prone to undergo reprogramming exhibit high mitochondrial membrane potential and display a hybrid metabolism. We conclude that MYC proteins orchestrate a rewiring of somatic cell metabolism early in cell reprogramming, whereby somatic cells acquire the phenotypic plasticity necessary for their transition to pluripotency in response to either intrinsic or external cues.
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MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas c-myc
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Reprogramação Celular
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Células Híbridas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article