Carbene-Catalyzed [4 + 2] Annulation of 2 H-Azirine-2-carboxaldehydes with Ketones via Azolium Aza-Dienolate Intermediate.
Org Lett
; 20(23): 7641-7644, 2018 12 07.
Article
em En
| MEDLINE
| ID: mdl-30479131
ABSTRACT
A new carbene-catalyzed [4 + 2] annulation of 2 H-azirine-2-carbaldehydes with ketones was developed, thus providing the 2,3-dihydro-6 H-1,3-oxazin-6-one core structures with broad scope and good to excellent yields. Notably, the azolium aza-dienolates generated from the addition of NHCs to 2 H-azirines are first uncovered.
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MEDLINE
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En
Ano de publicação:
2018
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Article