IL-17A-mediated ERK1/2/p65 signaling pathway is associated with cell apoptosis after non-alcoholic steatohepatitis.
IUBMB Life
; 71(3): 302-309, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30481403
ABSTRACT
Interleukin (IL)-17A is pro-inflammatory cytokine which has been identified as a noninvasive marker of the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the underlying role of IL-17A in NASH progression remains unclear. This study was designed to investigate the biological function and molecular mechanism of IL-17A in the induction of NASH. The results showed that IL-17A was highly expressed in high-fat diet (HFD)-induced NASH mouse model. Intravenous injection of IL-17A exacerbated steatohepatitis process via promoting hepatocyte apoptosis. Furthermore, IL-17A-induced apoptosis was mediated by ERK1/2/p65 signaling pathway. In conclusion, we demonstrated that IL-17A-mediated ERK1/2/p65 signaling pathway was a promising target for the treatment of NASH. © 2018 IUBMB Life, 71(3)302-309, 2019.
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Base de dados:
MEDLINE
Assunto principal:
Apoptose
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Proteína Quinase 1 Ativada por Mitógeno
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Interleucina-17
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Proteína Quinase 3 Ativada por Mitógeno
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Fator de Transcrição RelA
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Hepatopatia Gordurosa não Alcoólica
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article