Telomere length and redox balance in master endurance runners: The role of nitric oxide.
Exp Gerontol
; 117: 113-118, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30481549
ABSTRACT
Leukocyte telomere length (LTL), a biological marker of aging that is associated with age-related diseases, is longer in master endurance runners (ER) than age-matched controls, but the underlying mechanisms are poorly investigated. The LTL, nitric oxide (NO), and redox balance of ER master runners were analyzed and compared to untrained middle-aged and young adults. We hypothesized that NO and redox balance at baseline would be related to longer LTL in ER athletes. Participants (nâ¯=â¯38) were long-term ER runners (nâ¯=â¯10; 51.6⯱â¯5.2â¯yrs.; 28.4⯱â¯9.4â¯yrs. of experience) and untrained age-matched (nâ¯=â¯17; 46.6⯱â¯7.1â¯yrs) and young controls (nâ¯=â¯11; 21.8⯱â¯4.0â¯yrs). Volunteers were assessed for anamnesis, anthropometrics, and blood sampling. Measurements of pro-and anti-oxidant status and DNA extraction were performed using commercial kits. Relative LTL was determined with qPCR analyses (T/S). While the middle-aged controls had shorter LTL than the young group, no difference was observed between ER athletes and young participants. A large effect size between the LTL of ER athletes and middle-aged controls (dâ¯=â¯0.85) was also observed. The ER athletes and untrained young group had better redox balance according to antioxidant/pro-oxidant ratios compared to middle-aged untrained participants, which also had lower values for redox parameters (TEAC/TBARS, SOD/TBARS, and CAT/TBARS; all pâ¯<â¯0.05). Furthermore, the NO level of ER athletes (175.2⯱â¯31.9⯵M) was higher (pâ¯<â¯0.05) than middle-aged controls (67.2⯱â¯23.3⯵M) and young participants (129.2⯱â¯17.3⯵M), with a significant correlation with LTL (râ¯=â¯0.766; pâ¯=â¯0.02). In conclusion, ER runners have longer LTL than age-matched controls, which in turn may be related to better NO bioavailability and redox balance status.
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MEDLINE
Assunto principal:
Corrida
/
Envelhecimento
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Homeostase do Telômero
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article