Sulfatides ameliorate experimental autoimmune neuritis by suppressing Th1/Th17 cells.
J Neuroimmunol
; 326: 55-61, 2019 01 15.
Article
em En
| MEDLINE
| ID: mdl-30481614
ABSTRACT
Sulfatides have immunomodulatory functions, and play protective roles in multiple autoimmune diseases. In the present study, we showed that sulfatides ameliorated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin, which was associated with decreased proportions of Th1 and Th17 cells. Furthermore, compared control group, cells from sulfatide-treated rats exhibited lower potential in proliferation and IL-17 secretion in the presence of BPM or ConA in vitro. Moreover, sulfatides also reduced the proportions of NK and NKT cells. In summary, our study indicated that sulfatides might become a new therapeutic agent in Guillain-Barré syndrome in the future.
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Base de dados:
MEDLINE
Assunto principal:
Sulfoglicoesfingolipídeos
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Células Th1
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Células Th17
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Neurite Autoimune Experimental
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article