Broadly protective influenza vaccines: design and production platforms.
Curr Opin Virol
; 34: 1-9, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30497050
ABSTRACT
Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in â¼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging influenza viruses. To address the need for rapid efficacious vaccines that could mitigate the impact of seasonal and future pandemics, multiple platforms are under development and/or investigation. What is clear is that any universal vaccine must provide long-lasting cross-protective immunity that can induce both B and T cell responses. This review will explore some of the universal influenza vaccine platforms in the contexts of their ability to induce long-lasting and cross-protective T cell immunity.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
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Vacinas contra Influenza
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Influenza Humana
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Proteção Cruzada
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Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article