Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids.
Chem Commun (Camb)
; 54(100): 14148-14151, 2018 Dec 13.
Article
em En
| MEDLINE
| ID: mdl-30506077
ABSTRACT
A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.
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MEDLINE
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En
Ano de publicação:
2018
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Article