Expression and function of Slc34 sodium-phosphate co-transporters in skeleton and teeth.
Pflugers Arch
; 471(1): 175-184, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30511265
ABSTRACT
Under normal physiological condition, the biomineralization process is limited to skeletal tissues and teeth and occurs throughout the individual's life. Biomineralization is an actively regulated process involving the progressive mineralization of the extracellular matrix secreted by osteoblasts in bone or odontoblasts and ameloblasts in tooth. Although the detailed molecular mechanisms underlying the formation of calcium-phosphate apatite crystals are still debated, it is suggested that calcium and phosphate may need to be transported across the membrane of the mineralizing cell, suggesting a pivotal role of phosphate transporters in bone and tooth mineralization. In this context, this short review describes the current knowledge on the role of Slc34 Na+-phosphate transporters in skeletal and tooth mineralization.
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Base de dados:
MEDLINE
Assunto principal:
Dente
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Osso e Ossos
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Proteínas Cotransportadoras de Sódio-Fosfato Tipo II
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article