Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes.
Bioinformatics
; 35(14): 2515-2517, 2019 07 15.
Article
em En
| MEDLINE
| ID: mdl-30517594
ABSTRACT
SUMMARY:
Results from hundreds of genome-wide association studies (GWAS) are now freely available and offer a catalogue of the association between phenotypes across medicine with variants in the genome. With the aim of using this data to better understand therapeutic mechanisms, we have developed Drug Targetor, a web interface that allows the generation and exploration of drug-target networks of hundreds of phenotypes using GWAS data. Drug Targetor networks consist of drug and target nodes ordered by genetic association and connected by drug-target or drug-gene relationship. We show that Drug Targetor can help prioritize drugs, targets and drug-target interactions for a specific phenotype based on genetic evidence. AVAILABILITY AND IMPLEMENTATION Drug Targetor v1.21 is a web application freely available online at drugtargetor.com and under MIT licence. The source code can be found at https//github.com/hagax8/drugtargetor. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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MEDLINE
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Software
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En
Ano de publicação:
2019
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Article