Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome: supporting evidence for an association between the PCNT gene and schizophrenia.
Psychiatr Genet
; 29(2): 57-60, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30531648
ABSTRACT
Schizophrenia is a genetically complex disease that is related to neurodevelopmental abnormalities. Several genetic polymorphisms and genetic syndromes associated with neurodevelopmental processes have been linked to schizophrenia. In this case report, we present a case with an association between microcephalic osteodysplastic primordial dwarfism type II and schizophrenia. Microcephalic osteodysplastic primordial dwarfism type II syndrome is a rare, autosomal recessive disease that occurs as a result of the mutations in the pericentrin (PCNT) gene that are responsible for cell cycle and division. In this report, we discuss the possible association between the PCNT gene and schizophrenia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteocondrodisplasias
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Esquizofrenia
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Nanismo
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Retardo do Crescimento Fetal
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Microcefalia
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Antígenos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article