Osteoblastic differentiation improved by bezafibrate-induced mitochondrial biogenesis in deciduous tooth-derived pulp stem cells from a child with Leigh syndrome.

Han, Xu; Nonaka, Kentaro; Kato, Hiroki; Yamaza, Haruyoshi; Sato, Hiroshi; Kifune, Takashi; Hirofuji, Yuta; Masuda, Keiji

Han, Xu; Nonaka, Kentaro; Kato, Hiroki; Yamaza, Haruyoshi; Sato, Hiroshi; Kifune, Takashi; Hirofuji, Yuta; Masuda, Keiji.

Afiliação

Han X; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Nonaka K; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Kato H; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Yamaza H; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Sato H; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Kifune T; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Hirofuji Y; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Masuda K; Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.

Biochem Biophys Rep ; 17: 32-37, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30533535

Palavras-chave

BZF, bezafibrate; Bezafibrate; DRP1, dynamin-related protein 1; Dental pulp stem cell; LS, Leigh syndrome; Leigh syndrome; MMP, Mitochondrial membrane potential; Mitochondrial biogenesis; OXPHOS, oxidative phosphorylation; Osteogenesis; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator-1α; PPAR, peroxisome proliferator-activated receptor; RC complex I, respiratory chain complex I; SHED, Stem cells from human exfoliated deciduous teeth; mtDNA, mitochondrial DNA

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article