Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids.
Chem Sci
; 9(44): 8363-8368, 2018 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-30542583
ABSTRACT
A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article