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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids.
Matsuura, Rei; Jankins, Tanner C; Hill, David E; Yang, Kin S; Gallego, Gary M; Yang, Shouliang; He, Mingying; Wang, Fen; Marsters, Rohan P; McAlpine, Indrawan; Engle, Keary M.
Afiliação
  • Matsuura R; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
  • Jankins TC; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
  • Hill DE; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
  • Yang KS; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
  • Gallego GM; Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
  • Yang S; Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
  • He M; Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
  • Wang F; Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
  • Marsters RP; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
  • McAlpine I; Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
  • Engle KM; Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email: keary@scripps.edu.
Chem Sci ; 9(44): 8363-8368, 2018 Nov 28.
Article em En | MEDLINE | ID: mdl-30542583
ABSTRACT
A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article