In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds.
Org Lett
; 20(24): 7912-7915, 2018 12 21.
Article
em En
| MEDLINE
| ID: mdl-30543298
ABSTRACT
A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in 82-92% yields. The potential utility of this synthetic strategy has been demonstrated in model studies for the construction the core structures of 1α,8α4α,5α-diepoxy-4,5-dihydroosmitopsin and cortistatin A.
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MEDLINE
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En
Ano de publicação:
2018
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Article